Renal angiomyolipomas, affecting up to 80% of TSC patients,1,2 occur bilaterally, are often multiple,3,4 and are associated with hemorrhage, renal insufficiency, potential renal failure, and even death.5,6

References: 1. Franz DN. J Child Neurol. 2004;19(9):690-698. 2. Ewalt DH, et al. J Urol. 1998;160(1):141-145. 3. Cook JA, et al. J Med Genet. 1996;33(6):480-484. 4. Koo KC, et al. Yonsei Med J. 2010;51(5):728-734. 5. Nelson CP, Sanda MG. J Urol. 2002;168(4 Pt 1):1315-1325. 6. Harabayashi T, et al. J Urol. 2004;171:102-105.

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Cortical tubers may serve as an epileptogenic focus.1,2 Subependymal nodules (SENs) have the potential to evolve into life-threatening subependymal giant cell astrocytomas (SEGAs).3-5 SEGAs may lead to hydrocephalus and increased intracranial pressure.3,6

References: 1. Gallagher A, et al. Dev Med Child Neurol. 2010;52(11):1062-1065. 2. Petrova LD. Am J Electroneurodiagnostic Technol. 2011;51(1):5-15. 3. Curatolo P, et al. Lancet. 2008;372(9639):657-668. 4. Yates JRW. Eur J Hum Genet. 2006;14(10):1065-1073. 5. Kalantari BN, Salamon N. Am J Radiol. 2008;190(5):W304-W309. 6. Crino PB, et al. N Engl J Med. 2006;355(13):1345-1356.

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Lymphangioleiomyomatosis (LAM) can be found in 30% to 40% of adult women with TSC1 and may lead to difficulty breathing, lung collapse, and respiratory failure.1,2

References: 1. Johnson SR, et al. Eur Respir J. 2010;35(1):14-26. 2. Johnson SR. Eur Respir J. 2006;27(5):1056-1065.

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Because TSC is an unpredictable and complex disease that can affect many parts of the body at any given time,1,2 patient care requires active monitoring by multiple specialists and regular, lifelong follow-up.

References: 1. Crino PB, et al. N Engl J Med. 2006;355(13):1345-1356. 2. Franz DN. http://emedicine.medscape.com/article/1177711-overview. Accessed March 27, 2012.

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TSC Face Time Expert Videos Center

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Navigate your way through the disease with these helpful videos from TSC experts. You can choose a topic from the menu above or simply scroll over the body to see different areas affected by TSC.

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TSC Face Time Expert Videos Center
TSCeBook

Bring courage, inspiration, and support to the TSC community with Turbo & Scott

Turbo and Scott

Tell your patients and their loved ones today about Turbo and Scott - a fun and educational eBook, also available in an animated video!

Raise awareness today!

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Please note, the TSC eBook is for U.S. residents only.

TSC Differential Diagnosis Tool

ONLINE DIAGNOSTIC ANALYSIS

Delve into TSC symptoms, refer to corresponding images, and determine specific indicators for diagnosis.

References

1. Roach ES, Gomez MR, Northrup H. Tuberous Sclerosis Complex consensus conference: revised clinical diagnostic criteria. J. Child Neurol.
1998; 13(12):624-628. 2.Leung AKC, Robson WLM. Tuberous Sclerosis complex: a review. J. Peadiatr Health Care. 2007;21(2):108-114.

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